Related Experiment Videos
A durable load bearing muscle to prosthetic coupling
David B Melvin1, Brad Klosterman, Beth R Gramza
1Department of Surgery, University of Cincinnati, Cincinnati, Ohio 45267-0558, USA.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|June 7, 2003
Summary
The MyoCoupler device significantly improves long-term muscle-to-prosthetic interface durability by integrating ultrafine polymer fibers. This novel approach enhances force transfer for advanced mechanical support devices.
Area of Science:
- Biomaterials Engineering
- Tissue Engineering
- Prosthetics and Orthotics
Background:
- Skeletal muscle interfaces for mechanical support devices often lack durability due to high pressures and limited fixation areas.
- Current methods using suture or clamp fixation struggle to withstand repetitive forces, leading to tissue damage.
Purpose of the Study:
- To evaluate the long-term bonding strength and tissue integration of the MyoCoupler device.
- To assess the MyoCoupler's efficacy in enhancing muscle-to-prosthetic force transfer for durable interfaces.
Main Methods:
- Implantation of MyoCouplers and control devices (suture fixation) in rabbit posterior tibial muscles for up to 90 days.
- Pull-out strength testing at various time points (10-90 days) and histological analysis of tissue integration.
Main Results:
- MyoCoupler demonstrated significantly higher pull-out strength compared to controls across all tested periods (p < 0.00001).
- Histology confirmed fibrous tissue integration with 88% of fiber surfaces showing proximity to tissue structures.
- Bond strength remained robust over 90 days, indicating sustained interface integrity.
Conclusions:
- The MyoCoupler device offers a durable and effective solution for muscle-to-prosthetic interfaces.
- Findings support the development of muscle-powered mechanisms for artificial hearts and other assistive devices.