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Physiological adaptation to a nonpulsatile biventricular assist system.
Noriyuki Murai1, Seiji Ichikawa, Kuniyoshi Watanabe
1Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Artificial Organs Research Laboratory, Houston, Texas, USA.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|June 7, 2003
Summary
Calves adapted to nonpulsatile biventricular assist systems (NPBVAS) within two weeks. Physiological and hemodynamic parameters normalized, indicating successful integration of the NPBVAS with the native heart.
Area of Science:
- Cardiovascular Science
- Biomedical Engineering
- Medical Device Technology
Background:
- Physiological adaptation to nonpulsatile biventricular assist systems (NPBVAS) requires further investigation.
- Understanding recipient adaptation is crucial for advancing mechanical circulatory support.
Purpose of the Study:
- To evaluate the physiological adaptation of experimental animals to NPBVAS implantation.
- To assess hemodynamic and blood gas changes post-NPBVAS implantation.
Main Methods:
- Retrospective analysis of blood gas and hemodynamic data from four long-term NPBVAS experiments in calves.
- Prospective experiment to confirm retrospective findings.
- Monitoring of O2 content, total blood flow, and hemodynamic parameters.
Main Results:
- A correlation between O2 content and pulmonary artery blood flow emerged within two weeks post-implantation.
- Hemodynamic parameters normalized approximately 14 days after NPBVAS implantation.
- Easier blood pump controllability was observed after two weeks.
Conclusions:
- The native heart adapts to NPBVAS by reducing cardiac output within two weeks.
- NPBVAS demonstrates physiological compatibility and simplifies management after a two-week adaptation period.
- Successful physiological adaptation to NPBVAS can be established within two postoperative weeks.