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Organoplatinum(II) complexes as a color biomarker in solid-phase peptide chemistry and screening
Gabriela Guillena1, Koen M Halkes, Gema Rodríguez
1Debye Institute, Department of Metal-Mediated Synthesis, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
Organic Letters
|June 7, 2003
Abstract:
[reaction: see text] A novel organoplatinum(II) biomarker is introduced to facilitate the solid-phase screening of combinatorial libraries for substrates and inhibitors of enzymes and receptors. The robust organoplatinum(II) biomarker can be incorporated, on amine functions, in peptides using standard peptide coupling techniques. The chemistry, stability, and (reversible) coloration process with KI(3) of the organoplatinum(II) biomarker was investigated.