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Updated: Sep 25, 2026

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
Published on: April 24, 2021
Molecular pathways of endoplasmic reticulum dysfunctions: possible cause of cell death in the nervous system
J Lehotský1, P Kaplán, E Babusíková
1Comenius University, Jessenius Fculty of Medicine, Department of Medical Biochemistry, Martin, Slovak Republic. Lehotsky@jfmed.uniba.sk
Abstract:
This review summarizes recent information on the role of calcium in the process of neuronal injury with special attention to the role of calcium stores in the endoplasmic reticulum (ER). Experimental results present evidence that ER is the site of complex processes such as calcium storage, synthesis and folding of proteins and cell response to stress. ER function is impaired in many acute and chronic diseases of the brain which in turn induce calcium store depletion and conserved stress responses. Understanding the mechanisms leading to ER dysfunction may lead to recognition of neuronal protection strategies.
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