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Related Experiment Videos

Practice parameter: temporal lobe and localized neocortical resections for epilepsy.

Jerome Engel1, Samuel Wiebe, Jacqueline French

  • 1Reed Neurological Research Center, Department of Neurology, Los Angeles, CA 90095-1769, USA. engel@ucla.edu

Epilepsia
|June 7, 2003
PubMed
Summary
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Anteromesial temporal lobe resection offers greater seizure relief than medication for complex partial seizures. Referral to epilepsy surgery centers is recommended for improved outcomes.

Area of Science:

  • Neurosurgery
  • Epileptology
  • Clinical Neurology

Background:

  • Complex partial seizures significantly impact quality of life.
  • Surgical interventions are considered for refractory epilepsy.

Purpose of the Study:

  • Evaluate the effectiveness of anteromesial temporal lobe and neocortical resections.
  • Compare surgical outcomes with antiepileptic drug treatment for disabling seizures.

Main Methods:

  • Systematic review and analysis of literature published since 1990.
  • Inclusion of randomized controlled trials and case series.

Main Results:

  • A Class I trial showed 58% seizure freedom after anteromesial temporal lobe resection versus 8% with medication.

Related Experiment Videos

  • Surgery improved quality of life and social function with low mortality/morbidity.
  • Class IV studies on temporal lobe and neocortical resections showed similar benefits.

    • Conclusions:

    • Anteromesial temporal lobe resection provides superior seizure control compared to antiepileptic drugs.
    • Referral to epilepsy surgery centers is advised for eligible patients.
    • Further research is needed for neocortical resections and early surgical intervention.