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Diffusion-weighted imaging abnormalities in the splenium after seizures.

Joel Oster1, Colin Doherty, P Ellen Grant

  • 1Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

Epilepsia
|June 7, 2003
PubMed
Summary
This summary is machine-generated.

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Seizures, not medication, cause temporary white matter changes in the corpus callosum splenium. These acute postictal findings highlight the impact of seizures on brain pathways.

Area of Science:

  • Neuroimaging
  • Epileptology
  • Neurology

Background:

  • Transient T2 signal abnormalities in the corpus callosum splenium post-seizures are sometimes linked to anticonvulsant medication toxicity.
  • Bitemporal epilepsy is a common form of epilepsy.

Observation:

  • Two patients with bitemporal epilepsy presented with acute postictal imaging findings.
  • Increased T2 signal and decreased apparent diffusion coefficient (ADC) were observed in the splenium of the corpus callosum.

Findings:

  • The observed imaging changes, including increased T2 signal and decreased ADC in the splenium, were directly associated with acute seizures.
  • These findings suggest seizures themselves, rather than anticonvulsant medications, are responsible for transient white matter abnormalities.

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Implications:

  • This study identifies an unusual acute postictal imaging finding.
  • It emphasizes the involvement of the corpus callosum splenium, a critical white matter tract.
  • The results suggest seizures per se can induce transient white matter changes.