5-amino-salicylate in the management of inflammatory bowel disease

The role of aminosalicylates in the treatment of idiopathic bowel disease is reviewed, with emphasis on how the different formulations can be used in different clinical manifestations. Although not fully understood, the possible mechanisms of action of these agents are discussed and their adverse reactions noted. Their use in clinical practice, both in acute disease and in remission, is outlined with particular reference to the different delivery characteristics of the aminosalicylates, thus allowing their use according to the distribution of the disease. Finally, benefits that might come from maintenance therapy, including possible reduction in post-operative recurrence of Crohn's disease and the risk of colorectal cancer are mentioned.