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Piperacillin induced bone marrow suppression: a case report.

Ashish Kumar1, Gourdas Choudhuri, Rakesh Aggarwal

  • 1Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India. ashishk@sgpgi.ac.in

BMC Clinical Pharmacology
|June 7, 2003
PubMed
Summary
This summary is machine-generated.

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Piperacillin, a common antibiotic, can cause serious bone marrow suppression, including neutropenia and thrombocytopenia. This adverse effect necessitates careful patient monitoring during treatment with piperacillin or piperacillin/tazobactam.

Area of Science:

  • Pharmacology
  • Hematology
  • Infectious Diseases

Background:

  • Piperacillin and piperacillin/tazobactam are widely used antibiotics.
  • These antibiotics are generally considered safe for clinical use.

Observation:

  • A case study involving a 19-year-old male patient treated for an infected pancreatic pseudocyst.
  • The patient received piperacillin followed by piperacillin/tazobactam for 21 days.

Findings:

  • The patient developed neutropenia and thrombocytopenia after 21 days of antibiotic treatment.
  • Bone marrow suppression symptoms resolved rapidly upon discontinuation of piperacillin/tazobactam.
  • The clinical timeline strongly suggested piperacillin as the causative agent for bone marrow suppression.

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Implications:

  • Bone marrow suppression is a significant, albeit rare, adverse effect of piperacillin.
  • Clinicians should maintain a high index of suspicion for piperacillin-induced bone marrow suppression.
  • Awareness of this potential toxicity is crucial for safe patient management.