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Related Experiment Videos

A mitochondrial rhomboid protease.

Alexander M van der Bliek1, Carla M Koehler

  • 1Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.

Developmental Cell
|June 7, 2003
PubMed
Summary

Rhomboid proteases, usually in the secretory pathway, are now found in yeast mitochondria. These enzymes cleave proteins within the mitochondria, indicating a new regulatory role in this organelle.

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Area of Science:

  • Mitochondrial biology
  • Protease function
  • Cellular regulation

Background:

  • Rhomboid proteases are integral membrane proteins.
  • They are typically involved in cleaving peptide hormones in the secretory pathway.

Purpose of the Study:

  • To investigate the role of rhomboid proteases in mitochondria.
  • To identify novel functions of rhomboid proteases beyond the secretory pathway.

Main Methods:

  • Analysis of yeast mitochondrial proteases.
  • Identification of rhomboid protease substrates within mitochondria.

Main Results:

  • Yeast mitochondria possess a rhomboid protease.
  • This protease cleaves two specific mitochondrial intermembrane space proteins.

Conclusions:

  • Rhomboid proteases have a regulatory function within mitochondria.
  • Mitochondrial rhomboid proteases represent a novel class of organelle-specific proteases.

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