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[Function, molecular structure and gene expression of granulocyte colony-stimulating factor]

S Asano1

  • 1Department of Hematology-Oncology, University of Tokyo.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 1, 1992
PubMed

Human granulocyte colony-stimulating factor, a 19KD glycoprotein consisting of 174 amino acids, is one of the physiological regulators mainly produced by monocytes-macrophages, fibroblasts, and endothelial cells, under various stimulations such as neutropenias and infections. The molecule specifically and markedly stimulates the production of neutrophils associated with an expansion of the hemopoietic stem cells/progenitor cells, proliferates myeloid leukemia cells, releases these cells into blood, and elevates the functional activities of neutrophils. Under the favor of the activities, recombinant human granulocyte colony-stimulating factor has now become an epoch-making agents for the treatment of various disorders.

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