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[Function, molecular structure and gene expression of granulocyte colony-stimulating factor].
1Department of Hematology-Oncology, University of Tokyo.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 1, 1992
Summary
Human granulocyte colony-stimulating factor (G-CSF) regulates neutrophil production. Recombinant G-CSF is a groundbreaking treatment for various disorders, stimulating neutrophil activity and expansion of hematopoietic stem cells.
Area of Science:
- Biochemistry
- Hematology
- Immunology
Context:
- Granulocyte colony-stimulating factor (G-CSF) is a key regulator of neutrophil production.
- Produced by monocytes-macrophages, fibroblasts, and endothelial cells.
- Stimulated by conditions like neutropenias and infections.
Purpose:
- To describe the role and function of human granulocyte colony-stimulating factor (G-CSF).
- To highlight the therapeutic potential of recombinant G-CSF.
Summary:
- Human G-CSF is a 19KD glycoprotein that stimulates neutrophil production and enhances their functional activities.
- It promotes the expansion of hemopoietic stem cells and progenitor cells.
- G-CSF also proliferates myeloid leukemia cells and facilitates their release into circulation.
Impact:
- Recombinant G-CSF has emerged as a significant therapeutic agent.
- It is effective in treating various disorders characterized by neutrophil deficiency or dysfunction.
- G-CSF plays a crucial role in managing neutropenias and supporting recovery during infections.