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Bovine spongiform encephalopathy in sheep?

B E C Schreuder1, R A Somerville

  • 1BSE/scrapie specialist, Central Institute for Animal Disease Control (CIDC)-Lelystad, PO Box 2004, 8203 AA Lelystad, The Netherlands.

Revue Scientifique Et Technique (International Office of Epizootics)
|June 10, 2003
PubMed
Summary

Bovine spongiform encephalopathy (BSE) in sheep is hypothetical but causes concern. Research explores experimental BSE in sheep, infectivity, and methods to distinguish it from scrapie, aiding risk assessment.

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Area of Science:

  • Veterinary Medicine
  • Neuroscience
  • Epidemiology

Background:

  • Bovine spongiform encephalopathy (BSE) has not been confirmed in sheep naturally.
  • Rumors of BSE-like isolates in sheep have caused significant industry and public concern.
  • Implementing risk assessments and preventative measures is challenging without confirmed cases.

Purpose of the Study:

  • To review existing knowledge on experimental BSE in sheep.
  • To discuss infectivity distribution, risk assessment, and management strategies.
  • To explore methods for differentiating BSE from scrapie in sheep.

Main Methods:

  • Literature review on experimental BSE in sheep.
  • Analysis of infectivity distribution within the ovine host.

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  • Evaluation of diagnostic methods for differentiating transmissible spongiform encephalopathies (TSEs).

    • Main Results:

    • Experimental data on BSE in sheep is limited.
    • Promising new methods for initial screening of TSE isolates are emerging.
    • Classical strain-typing in mouse models remains essential for validation.

    Conclusions:

    • Distinguishing BSE from scrapie in sheep requires validated diagnostic tools.
    • Further research is needed to address the hypothetical risk of BSE in sheep.
    • Risk management strategies are crucial despite the absence of confirmed natural cases.