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Related Experiment Videos

Prophage genomics.

Carlos Canchaya1, Caroline Proux, Ghislain Fournous

  • 1Nestlé Research Center, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland.

Microbiology and Molecular Biology Reviews : MMBR
|June 10, 2003
PubMed
Summary
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Bacterial genomes frequently contain prophage sequences that decay through mutations and DNA deletion. This study examines prophage genomics and their role in bacterial evolution across diverse species.

Area of Science:

  • Genomics
  • Microbiology
  • Evolutionary Biology

Background:

  • Prophage sequences are prevalent in bacterial genomes.
  • Integrated prophages undergo complex decay processes including mutations, rearrangements, and DNA deletion.
  • Identifying these altered prophage sequences presents technical challenges.

Purpose of the Study:

  • To review technical difficulties in defining altered prophage sequences.
  • To discuss theoretical frameworks for phage-bacterium genomic interactions.
  • To analyze prophage genomics across diverse bacterial groups and ecological niches.

Main Methods:

  • Screening of published genome sequences from eubacteria (low- and high-G+C gram-positive bacteria, gamma-proteobacteria).
  • Using Streptococcus pyogenes prophages as a test case for evolutionary predictions.

Related Experiment Videos

  • Analyzing genomes of human, animal, and plant pathogens, commensal, and free-living bacteria.

    • Main Results:

    • Prophages integrated into bacterial genomes are subject to decay.
    • Selection pressure significantly shapes prophage genomes in specific bacterial groups (low-G+C gram-positive and gamma-proteobacteria).
    • Prophage genomics principles appear consistent across different bacterial ecological niches and phylogenetic groups.

    Conclusions:

    • Prophage decay is a common phenomenon in bacterial genomes.
    • Phage-bacterium interactions at the genomic level are complex and influenced by host selection pressures.
    • Understanding prophage genomics is crucial for studying bacterial evolution, particularly in pathogenic species.