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[Familial aortic dissection; cases involving a father, mother, and son]

K Horike1, M Kanoh, A Kurushima

  • 1Department of Cardiovascular Surgery, National Zentsuji Hospital, Zentsuji, Japan.

Kyobu Geka. the Japanese Journal of Thoracic Surgery
|June 11, 2003
PubMed

Insights

Familial aortic dissection, rare outside Marfan syndrome, occurred in a three-generation family. This case highlights the need for further research into genetic aortic dissection mechanisms.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Medical Case Reports

Background:

  • Familial occurrence of aortic dissection is uncommon, particularly when not associated with Marfan syndrome.
  • Understanding the genetic basis of aortic dissection is crucial for identifying at-risk individuals and families.

Observation:

  • A family presented with three cases of acute aortic dissection (Stanford type A): the father (79), mother (73), and son (48).
  • The father and son underwent successful surgical repair of the ascending aorta and aortic arch.
  • The mother experienced aortic rupture and cardiac arrest during transfer, succumbing despite resuscitation efforts.

Findings:

  • This report details a rare instance of familial aortic dissection affecting a parent-offspring trio.
  • The cases underscore the potential for non-syndromic hereditary factors contributing to aortic dissection.
  • Successful surgical interventions were performed on two family members, while one experienced a fatal rupture.

Implications:

  • Further investigation into the genetic underpinnings of aortic dissection is warranted.
  • Early identification and genetic counseling may be beneficial for families with a history of aortic dissection.
  • This case series contributes to the understanding of rare aortic dissection etiologies beyond known genetic syndromes.

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