Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Relapsing polychondritis with idiopathic hypoparathyroidism].

Shinya Okohchi1, Ryushi Tazawa, Yuichiro Kimura

  • 1Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980-8575, Japan.

Nihon Kokyuki Gakkai Zasshi = the Journal of the Japanese Respiratory Society
|June 11, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Growth of Palate in Unilateral Cleft Lip and Palate Patients Undergoing Two-stage Palatoplasty and Orthodontic Treatment.

The Bulletin of Tokyo Dental College·2018
Same author

Two-year Survey of Trends at Food Introduction Booth at Suidobashi Hospital of Tokyo Dental College.

The Bulletin of Tokyo Dental College·2018
Same author

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase.

Emerging infectious diseases·2018
Same author

[Clinical Characteristics of Adult Onset RSV Infection During Two Consecutive Winter Seasons].

Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases·2018
Same author

The Feature of Solitary Small Nodular Type of Hepatic Epithelioid Hemangioendothelioma.

Case reports in gastroenterology·2018
Same author

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents.

The New England journal of medicine·2018

Idiopathic hypoparathyroidism (IPH) can lead to tracheal stenosis, a rare complication. This case highlights a potential autoimmune link between IPH and relapsing polychondritis, offering new insights into disease mechanisms.

Area of Science:

  • Endocrinology
  • Rheumatology
  • Pulmonology

Background:

  • Idiopathic hypoparathyroidism (IPH) is a rare endocrine disorder characterized by deficient parathyroid hormone secretion.
  • IPH is often associated with autoimmune conditions and can manifest with extrathyroidal symptoms.

Observation:

  • A 49-year-old male patient with a history of IPH presented with progressive wheezing due to diffuse tracheal stenosis.
  • Diagnostic imaging revealed significant narrowing of the trachea, while laboratory tests confirmed hypoparathyroidism with basal ganglia calcification.
  • Despite steroid treatment, respiratory symptoms persisted, ultimately leading to respiratory failure and death.

Findings:

  • Autopsy confirmed tracheal stenosis with thickened, fibrotic tracheal walls and inflammatory cell infiltration, indicative of relapsing polychondritis.

Related Experiment Videos

  • This case represents the first documented association between relapsing polychondritis and idiopathic hypoparathyroidism.
  • The patient's sister also had a diagnosis of IPH, suggesting a potential genetic predisposition.

    • Implications:

    • The co-occurrence of IPH and relapsing polychondritis suggests a shared autoimmune pathogenesis.
    • This case may provide valuable insights into the underlying mechanisms of both rare conditions.
    • Further research into autoimmune pathways could elucidate the connection between endocrine and rheumatologic disorders.