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A system-approach method for the adjustment of time-varying continuous drug infusion in individual patients: a
Mária Durisová1, Ladislav Dedík
1Institute of Experimental Pharmacology, Slovak Academy of Sciences, 841 04 Bratislava, Slovak Republic.
Abstract:
The aim of this simulation study was to present a system-approach method for adjustment of continuous drug infusions at time-varying rates, aimed at achieving and then maintaining required drug concentration-time profiles in patients. The method presented can be used for safe and cost-effective individualization of drug dosing by computer-controlled infusion pumps. Utilization of this method is exemplified by simulation experiments, aimed at adjusting continuous infusions of Factor VIII (FVIII) at time-varying rates, which would theoretically yield required concentration-time profiles of FVIII in hemophilia A patients over several days.