Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autonomic nervous system controlled closed loop cardiac pacing.

A M Pichlmaier1, D Braile, E Ebner

  • 1Zentralinstitut für Biomedizinische Technik, Universität, Erlangen-Nürnberg, Germany.

Pacing and Clinical Electrophysiology : PACE
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intracortical BCI Performance is Robust to Changes in Attentional Load During Dual-Tasking.

bioRxiv : the preprint server for biology·2026
Same author

Expert-Level Detection of Epilepsy Markers in EEG on Short and Long Timescales.

NEJM AI·2025
Same author

Awareness of bone strength in patients with neuromuscular disorders: ERN EURO-NMD clinician survey and European patient survey.

Journal of the neurological sciences·2025
Same author

Building consensus on clinical outcome assessments for BCI devices. A summary of the 10th BCI society meeting 2023 workshop.

Journal of neural engineering·2024
Same author

Fecal Microbiota Transfer in Acute Graft-versus-Host Disease following Allogeneic Stem Cell Transplantation.

Visceral medicine·2024
Same author

Randomized phase-III study of low-dose cytarabine and etoposide + /- all-trans retinoic acid in older unfit patients with NPM1-mutated acute myeloid leukemia.

Scientific reports·2023
Same journal

Dual Coronary Sinus Lead Strategy to Avoid Tricuspid Valve Traversal in Biventricular Pacing.

Pacing and clinical electrophysiology : PACE·2026
Same journal

A Case of Permanent Pacemaker Implantation via the Epicardial Approach Using the 3830 Lead in an 11-Day-Old Neonate (With Follow-Up of the Above Case).

Pacing and clinical electrophysiology : PACE·2026
Same journal

Cryoballoon Versus Radiofrequency Ablation for Persistent Atrial Fibrillation: Meta-Analysis of Randomized Trials.

Pacing and clinical electrophysiology : PACE·2026
Same journal

Tilt Test Duration in Suspected Vasovagal Syncope: Temporal Patterns and Diagnostic Yield in Patients From Central China.

Pacing and clinical electrophysiology : PACE·2026
Same journal

Combined Leadless Pacing and Subcutaneous ICD Therapy in Long QT Syndromes.

Pacing and clinical electrophysiology : PACE·2026
Same journal

Association of Anesthesia Modality With Procedural Parameters and Clinical Outcomes in PVI for Atrial Fibrillation.

Pacing and clinical electrophysiology : PACE·2026
See all related articles

This study demonstrates a new pacemaker system that restores heart rate control in patients with chronotropic insufficiency. The autonomic nervous system (ANS) controlled pacemaker uses myocardial contractility to adjust heart rate, improving physiological regulation.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Physiology

Background:

  • Chronotropic insufficiency impairs the heart's ability to adjust rate with activity.
  • Current pacemakers often lack physiological responsiveness to autonomic nervous system (ANS) demands.
  • Restoring closed-loop cardiac control is crucial for improving patient quality of life.

Purpose of the Study:

  • To evaluate a novel pacemaker system for reestablishing closed-loop cardiac control in patients with chronotropic insufficiency.
  • To assess the ability of an autonomic nervous system (ANS) controlled pacemaker to adapt heart rate based on sympathetic tone.
  • To validate the ventricular inotropic parameter (VIP) as a direct input for pacemaker heart rate control.

Main Methods:

  • A multicenter clinical study involving over 200 patients implanted with autonomic nervous system (ANS) controlled pacemakers.

Related Experiment Videos

  • Measurement of intracardiac impedance via a ventricular electrode to derive the ventricular inotropic parameter (VIP).
  • Investigation through exercise tests, 24-hour ambulatory monitoring, psychological, and pharmacological challenges.

    • Main Results:

    • The study validated the appropriateness of paced heart rate changes correlating with sympathetic tone during exercise.
    • A significant correlation was observed between heart rate and sinus rate when detectable.
    • The preejection period (PEP) showed a correlation with the VIP-controlled heart rate, confirming system validity.

    Conclusions:

    • Autonomic nervous system (ANS) controlled pacemakers effectively restore physiological heart rate regulation in chronotropic insufficiency.
    • The ventricular inotropic parameter (VIP) derived from intracardiac impedance provides a reliable input for adaptive pacing.
    • This technology offers a promising approach to enhance cardiac control and patient outcomes.