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Emerging role of calprotectin in gastroenterology
Andrew Poullis1, Russell Foster, Michael A Mendall
1Gastroenterology, Endocrinology and Metabolism Division, St George's Hospital Medical School, London and Mayday University Hospital, Surrey, UK. apoullis@sghms.ac.uk
Abstract:
Calprotectin is a calcium and zinc binding protein of the S100 family derived predominantly from neutrophils and monocytes. It is detectable in body fluids and tissue samples and is emerging as a valuable marker in the diagnosis, and the monitoring and determining of the prognosis of commonly encountered gastroenterological conditions. Fecal calprotectin, in particular, has for a long time been regarded as a promising marker of gastrointestinal pathology and has now been established as a routine test in Norway and at several centers in the UK.