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Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance
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Pulse-wave velocity and cardiovascular risk factors in subjects with Helicobacter pylori infection

Kyoichi Adachi1, Noriyuki Arima, Toshiharu Takashima

  • 1Department of Internal Medicine II, Shimane Medical University, Izumo and Shimane Sogo Health Screening Center, Matsue, Japan.

Journal of Gastroenterology and Hepatology
|June 11, 2003
PubMed

Insights

Helicobacter pylori infection is linked to increased arterial stiffness in young adults, indicated by higher pulse-wave velocity. This association diminishes with age, suggesting H. pylori may play a role in early arteriosclerosis development.

Area of Science:

  • Cardiovascular Health
  • Infectious Diseases
  • Gerontology

Background:

  • Helicobacter pylori infection is associated with cardiovascular diseases.
  • The specific link between H. pylori and arteriosclerosis requires further investigation.

Purpose of the Study:

  • To investigate the role of H. pylori infection in the development of arteriosclerosis.

Main Methods:

  • Cross-sectional study of 996 individuals undergoing medical check-ups.
  • Assessed H. pylori infection status via serum antibodies.
  • Measured blood lipids, glucose, and arteriosclerotic parameters (SBP, ABI, PWV).

Main Results:

  • H. pylori-seropositive individuals showed significantly lower high-density lipoprotein cholesterol (HDLC) levels.
  • No overall differences in systolic blood pressure (SBP) or ankle-brachial index (ABI).
  • Higher pulse-wave velocity (PWV) observed in H. pylori-seropositive young individuals (<39 years).

Conclusions:

  • Arterial stiffness, measured by PWV, is greater in young H. pylori-positive subjects.
  • This difference in arterial stiffness is not observed in elderly individuals.
  • H. pylori infection may contribute to early-stage arteriosclerosis in younger populations.
Abstract

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