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Related Experiment Videos

Methotrexate-induced pulmonary lymphoma.

Celso T Ebeo1, Mirle R Girish, Ryland P Byrd

  • 1Veterans Affairs Medical Center, Mountain Home, and the Division of Pulmonary Medicine and Critical Care, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.

Chest
|June 11, 2003
PubMed
Summary
This summary is machine-generated.

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Methotrexate, used for rheumatoid arthritis (RA), may pose an oncogenic risk in some patients. Discontinuing this drug led to remission of a patient's diffuse large B-cell lymphoma.

Area of Science:

  • Rheumatology
  • Oncology
  • Immunology

Background:

  • Methotrexate is a cornerstone therapy for rheumatoid arthritis (RA), generally considered non-oncogenic at standard doses.
  • The potential oncogenic risk of methotrexate, particularly in conjunction with other factors, remains an area of investigation.

Observation:

  • A case report details a patient with RA who developed diffuse large B-cell lymphoma (DLBCL) after 5 years of weekly methotrexate treatment.
  • The patient presented with a positive serum IgG for Epstein-Barr virus (EBV).

Findings:

  • Discontinuation of methotrexate therapy resulted in the regression of the lymphoproliferative disorder.
  • No recurrence of DLBCL was observed for two years post-methotrexate cessation.

Implications:

Related Experiment Videos

  • This case suggests methotrexate may have oncogenic potential in a subset of RA patients, possibly those with latent Epstein-Barr virus infection.
  • The findings highlight the importance of monitoring for secondary malignancies in patients on long-term methotrexate therapy.