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Related Experiment Videos

Retinal function abnormalities in patients treated with vigabatrin.

Eyal Banin1, Ruth S Shalev, Alexey Obolensky

  • 1Department of Ophthalmology, Hadassah-Hebrew University Hospital, Jerusalem, Israel. banine@md.huji.ac.il

Archives of Ophthalmology (Chicago, Ill. : 1960)
|June 11, 2003
PubMed
Summary
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Vigabatrin, an epilepsy drug, may harm both central and peripheral vision. This study found it affects retinal function, complicating treatment decisions for patients with visual field constriction.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pharmacology

Background:

  • Vigabatrin is an antiepileptic drug.
  • It is associated with peripheral visual field constriction (VFC).

Purpose of the Study:

  • To evaluate central and peripheral retinal function in patients on vigabatrin therapy.
  • To assess the impact of vigabatrin on visual field constriction (VFC).

Main Methods:

  • Observational case series of six epilepsy patients on long-term vigabatrin.
  • Included clinical ophthalmologic examination, color vision testing, standard perimetry, and electroretinography.
  • Specialized computerized static perimetry was used in four patients.

Main Results:

  • Foveal cone electroretinographic amplitudes were reduced in most eyes tested.

Related Experiment Videos

  • Dark-adapted perimetry showed abnormal rod-derived visual fields in patients with VFC.
  • Rod-derived thresholds were normal in the patient without VFC.

    • Conclusions:

    • Vigabatrin impairs peripheral cone function (VFC) and affects foveal cone electroretinography.
    • The drug also impacts rod-derived visual fields.
    • Adverse effects on both central and peripheral vision complicate vigabatrin therapy decisions.