Related Experiment Video
Updated: Sep 25, 2026
An Experiment Using Functional Near-Infrared Spectroscopy and Robot-Assisted Multi-Joint Pointing Movements of the Lower Limb
Published on: June 7, 2024
Striatal activation during blepharospasm revealed by fMRI
Kerstin E Schmidt1, David E J Linden, Rainer Goebel
1Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt/Main, Germany. schmidt@mpih-frankfurt.mpg.de
Objective:
To investigate brain areas involved in the initiation and execution of eyelid spasm in patients with benign essential blepharospasm.
Methods:
The authors used fMRI and correlated the blood oxygenation level-dependent (BOLD) signal with epochs of frequent eyelid spasm in six patients and with epochs of voluntary eye blinks in four healthy subjects.
Results:
Spasm epochs were accompanied by activation in a subregion of the putamen in all patients, whereas voluntary blinking in healthy subjects was not. Other areas of activation common to patients and healthy subjects included frontal and parietal operculum, supplementary motor area, primary sensorimotor cortex, various visual areas, and the cerebellum.
Conclusions:
The striatum may be involved in the initiation or execution of eyelid spasm. Future studies, possibly including electromyography (EMG) during fMRI, are needed to detect the sequence and role of other concomitantly activated areas.
