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Related Experiment Videos

Intrafollicular blood flow during human ovulation.

T H Bourne1, D Jurkovic, J Waterstone

  • 1Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, London, UK.

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
|January 1, 1991
PubMed
Summary

Transvaginal ultrasound monitoring revealed intrafollicular angiogenesis and blood flow changes during ovulation. These vascularity shifts may predict ovulation, aiding conception or contraception efforts.

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Corrigendum to 'An age-related nomogram for antral follicle counts as a reference guide for reproductive decision making: an observational study of 7573 women' Reproductive BioMedicine Online 49:5 (2025) 104295.

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Area of Science:

  • Reproductive endocrinology
  • Medical imaging
  • Gynecology

Background:

  • Ovulation involves complex physiological changes within the ovarian follicle.
  • Monitoring follicular dynamics and vascularity is crucial for understanding reproductive processes.

Purpose of the Study:

  • To investigate intrafollicular blood flow and morphology changes during follicular rupture and ovulation using transvaginal ultrasonography.
  • To correlate these changes with hormonal fluctuations, specifically luteinizing hormone (LH) peaks.

Main Methods:

  • Transvaginal ultrasonography with color flow mapping was employed for detailed monitoring of a human volunteer's menstrual cycle.
  • Blood samples were analyzed for luteinizing hormone (LH) levels.
  • Follicular rupture and subsequent corpus luteum formation were observed and timed.

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Main Results:

  • Follicular rupture was preceded by a significant rise and peak in serum LH.
  • Visible blood vessels in the granulosa layer appeared at the LH peak, with oocyte-containing granulosa detaching prior to rupture.
  • Peak blood velocity occurred shortly after rupture, with increased impedance (resistance and pulsatility indices).
  • Follicular emptying and corpus haemorrhagicum formation were documented.

Conclusions:

  • Transvaginal ultrasonography with color flow mapping is a viable, relatively non-invasive method to monitor intrafollicular angiogenesis and blood flow dynamics.
  • Observed vascular changes correlate with ovulation and may serve as predictors of imminent ovulation.
  • Understanding these vascular changes could have implications for fertility treatments and contraception.