Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Indirect airway challenges.

G F Joos1, B O'Connor, S D Anderson

  • 1Dept Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium. guy.joos@rug.ac.be

The European Respiratory Journal
|June 12, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping EQ-5D-5L utility scores from the severe asthma questionnaire in the SHARP CRC registry.

Respiratory medicine·2026
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Society of Colon and Rectal Surgeons Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons: Canadian Surgery Forum, London, Ont., Sept. 19 to 22, 2002.

Canadian journal of surgery. Journal canadien de chirurgie·2023
Same author

A nearby long gamma-ray burst from a merger of compact objects.

Nature·2022
Same author

Impact of "early intervention" parent workshops on outcomes for caregivers of children with neurodisabilities: a mixed-methods study.

Disability and rehabilitation·2022
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Society, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, London, Ont. Sept. 15-18, 2011.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons Canadian Hepato-Pancreato-Biliary Society Canadian Society of Surgical Oncology Canadian Society of Colon and Rectal Surgeons: Victoria, BC Sept. 10-13, 2009.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same journal

Decoding the Lymphangioleiomyomatosis (LAM) Niche Microenvironment <i>via</i> Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics.

The European respiratory journal·2026
Same journal

ERS Statement on ultrasound guided interventions in respiratory disease.

The European respiratory journal·2026
Same journal

When symptoms and resting tests disagree in interstitial lung disease: a selective role for cardiopulmonary exercise testing.

The European respiratory journal·2026
Same journal

Clinical Practice Guideline for the diagnosis of Granulomatous-Lymphocytic Interstitial Lung Disease (GLILD) in patients with Common Variable Immunodeficiency Disorders (CVID) - an ERS Clinical Research Collaboration.

The European respiratory journal·2026
Same journal

SARS-CoV-2 (E)-protein induces rapid TLR2-mediated T cell activation in mouse lungs revealed by intravital lung microscopy.

The European respiratory journal·2026
Same journal

Functional characterization of <b><i>KCNA5</i></b> gene variants linked to pulmonary arterial hypertension.

The European respiratory journal·2026
See all related articles

Direct airway challenges are sensitive but not specific for asthma, unlike indirect stimuli like exercise or hypertonic aerosols. Indirect challenges better reflect airway inflammation and active asthma, aiding in clinical course assessment.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Direct airway challenges (e.g., methacholine) use agonists to directly affect airway smooth muscle, causing airflow limitation.
  • Indirect challenges trigger endogenous mediators, leading to airway smooth muscle contraction, reflecting airway inflammation.

Framework:

  • Direct challenges are standardized and sensitive for excluding asthma but lack specificity.
  • Indirect stimuli (exercise, hypertonic aerosols, adenosine) are more specific to active asthma and ongoing airway inflammation.

Implementation:

  • Indirect challenges are increasingly used to evaluate bronchial hyperresponsiveness prevalence and specific asthma issues like exercise-induced bronchoconstriction.
  • Some indirect challenges, like hypertonic saline and mannitol, can be combined with sputum induction for inflammatory cell assessment.

Related Experiment Videos

Implications:

  • Indirect challenges may offer a more clinically relevant marker for assessing asthma's clinical course by reflecting acute changes in airway inflammation.
  • Responsiveness to indirect stimuli can be influenced by inhaled steroids less than direct challenges, suggesting distinct pathophysiological insights.