Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperbaric oxygen improves healing in experimental rat colitis.

M L Akin1, B M Gulluoglu, H Uluutku

  • 1Gulhane Military Medical Academy, Marmara University School of Medicine, Istanbul, Turkey.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|June 12, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tobacco-derived particulates and the periodontal axis: Distinct cytotoxic and stress-related mechanisms in human gingival fibroblasts.

Scientific reports·2026
Same author

The first link between ADAMTS-13 and apoptosis in type 1 diabetic liver injury.

Histochemistry and cell biology·2025
Same author

Omission of axillary dissection after neoadjuvant systemic treatment in initially node-positive HER2-overexpressed and triple-negative breast cancer patients: SENATURK OTHER-NAC study.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2025
Same author

The association of microRNAs in the development of retinopathy of prematurity.

Journal of neonatal-perinatal medicine·2024
Same author

Impact of low-level laser therapy as an adjunct to non-surgical periodontal treatment on the levels of tissue plasminogen activator and plasminogen activator inhibitor 1 in Stage 3-4, Grade C periodontitis patients: a split-mouth, randomized control study.

Clinical oral investigations·2023
Same author

The effect of alpha-lipoic acid on oxidative parameters, SCUBE-1 and SCUBE-2 in hepatic ischemia-reperfusion injury in cholestatic rats.

European review for medical and pharmacological sciences·2023

Hyperbaric oxygen therapy shows therapeutic effects for chronic colitis in rats. It significantly reduced macroscopic damage and inflammation markers in this experimental model.

Area of Science:

  • Gastroenterology
  • Experimental Medicine
  • Biomedical Engineering

Background:

  • Colitis is a significant health concern characterized by intestinal inflammation.
  • Current treatments for colitis have limitations, necessitating the exploration of novel therapeutic strategies.
  • Oxidative stress and neutrophil infiltration are key contributors to colitis pathology.

Purpose of the Study:

  • To investigate the therapeutic potential of hyperbaric oxygen (HBO) treatment on experimentally induced colitis in rats.
  • To assess the effects of HBO on oxidative tissue damage, neutrophil accumulation, and histological alterations in colitis models.
  • To evaluate HBO's efficacy in both acute and chronic colitis induced by chemical agents.

Main Methods:

  • Induction of colitis in rats using 50% ethanol or 2,4,6-trinitrobenzene sulphonic acid (TNBS).

Related Experiment Videos

  • Administration of hyperbaric oxygen treatment for 2 or 14 days in acute and chronic colitis models.
  • Assessment of macroscopic and microscopic colonic damage, myeloperoxidase (MPO) activity, and serum carbonyl content.

    • Main Results:

    • Significant colonic tissue damage was observed in untreated acute and chronic colitis groups.
    • Hyperbaric oxygen treatment significantly ameliorated macroscopic damage in chronic TNBS-induced colitis.
    • HBO significantly reduced tissue MPO activity in acute colitis and decreased plasma carbonyl content in chronic colitis.
    • Microscopic changes showed non-significant amelioration across HBO-treated groups.

    Conclusions:

    • Hyperbaric oxygen treatment demonstrates significant therapeutic effects in ameliorating TNBS-induced chronic colitis in rats.
    • HBO may be a promising adjunctive therapy for managing chronic inflammatory bowel conditions.
    • Further research is warranted to elucidate the precise mechanisms and optimize HBO protocols for colitis treatment.