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Variants of the human NRAMP1 gene and susceptibility to tuberculosis in Morocco

J El Baghdadi1, N Remus, A Benslimane

  • 1Service de Génétique Microbienne, Institut Pasteur du Maroc, Casablanca, Maroc.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|June 12, 2003
PubMed

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...