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Effect of sodium pentosan polysulphate on the thrombogenicity of prothrombin complex concentrates
H P Klöcking1, G Dornheim, H Schulze-Riewald
1Institute of Pharmacology and Toxicology, Medical Academy Erfurt, FRG.
Thrombosis Research
|July 1, 1992
Abstract:
The addition of pentosan polysulphate sodium (NaPPS) to thrombogenic prothrombin complex concentrates (PCC) dose-dependently reduces or abolishes thrombus formation in rats in the stasis model acc. to Wessler. However, no reduction of thrombogenicity was found in PCC preparations manufactured in the presence of NaPPS.