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Updated: Sep 25, 2026
Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
Published on: July 23, 2012
Microarray analysis identifies interferon beta-regulated genes in multiple sclerosis
Fumiko Koike1, Jun-ichi Satoh, Sachiko Miyake
1Department of Immunology, National Institute of Neuroscience, NCNP, 4-1-1 Ogawahigashi, Tokyo 187-8502, Kodaira, Japan.
Abstract:
The molecular mechanisms for the interferon beta (IFNbeta) treatment of multiple sclerosis (MS) remain to be characterized. Using cDNA microarray technology, we have compared the gene expression profile of T and non-T cells derived from relapsing-remitting MS before and after treatment with IFNbeta-1b. IFNbeta treatment significantly altered expression of 21 genes out of 1263 at 3 and 6 months after treatment. These genes included nine with IFN-responsive promoter elements. Whereas there was no change in Th1 or Th2 marker genes, some of the changes were unexpected but coincided with the beneficial effect of IFNbeta in MS.
