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Updated: Aug 28, 2026

Murine Model of CD40-activation of B cells
Published on: March 5, 2010
Recent advances on the role of CD40 and dendritic cells in immunity and tolerance
Brendan O'Sullivan1, Ranjeny Thomas
1Center for Immunology and Cancer Research, Pricess Alexandra Hospital, University of Queensland, Queensland, Australia.
Abstract:
CD40 is a key signaling pathway for the function of B cells, monocytes, and dendritic cells in the immune system, and plays an important role in inflammatory pathways of nonhemopoietic cells. The NFkappaB family of transcription factors is a critical mediator in inflammation. NFkappaB is involved both in the regulation of CD40 expression and in cell signaling after CD40 ligation. This positive feedback loop linking NFkappaB and CD40 plays an important role in the control of the adaptive immune response, with fundamental implications for immunity and tolerance in vivo.
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