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Related Experiment Videos

Autism and auditory brain stem responses.

Ulf Rosenhall1, Viviann Nordin, Krister Brantberg

  • 1Department of Audiology/Institution of Clinical Neurosciences, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden. ulf.rosenhall@ks.se

Ear and Hearing
|June 12, 2003
PubMed
Summary
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Children with autism show auditory brain stem response (ABR) abnormalities, including prolonged latencies and wave abnormalities. These findings suggest potential brain stem or cochlear dysfunction in autism.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Audiology

Background:

  • Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition.
  • Auditory pathway abnormalities in children with autism have been debated for over 20 years.
  • Understanding these auditory pathway differences is crucial for diagnosis and intervention.

Purpose of the Study:

  • To investigate auditory brain stem response (ABR) abnormalities in children and adolescents with autistic disorder.
  • To determine if cochlear nerve or brain stem auditory pathways are affected in autism.
  • To describe the nature of any identified auditory pathway abnormalities.

Main Methods:

  • Auditory brain stem responses (ABR) were assessed in 153 children and adolescents with autistic disorder.

Related Experiment Videos

  • A subgroup of 101 children with normal hearing underwent in-depth ABR analysis.
  • Results were compared to an age-matched control group.

    • Main Results:

    • Significantly prolonged III-V interpeak latency (IPL) and lengthened ABR wave I and V latencies were observed in children with autism.
    • Over half (58%) of the normal-hearing autistic group exhibited abnormalities in at least one of eight ABR parameters.
    • Common findings included prolonged wave V (38%) and I-V IPL (28%), with 18% showing abnormal left-right latency differences.

    Conclusions:

    • The study confirms ABR abnormalities in children with autism, supporting previous research.
    • Probable explanations include brain stem lesions, occult cochlear dysfunction, or efferent cochlear system involvement.
    • These findings highlight the importance of auditory pathway assessment in autism.