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Published on: January 14, 2009
[The Bier block as an experimental tool to differentiate peripheral and central effects of analgesics on people]
Aims:
In this study the technique of intravenous regional anesthesia (Bier block) was evaluated as an experimental tool to differentiate peripheral and central effects of analgesics.
Methods:
Touch and pain thresholds were assessed under control conditions and during a prolonged Bier block. In addition, models of experimental pain and hyperalgesia were used (Capsaicin injection, histamine iontophoresis, pinch).
Results:
No signs of impaired function of Adelta- und C-fibers were found during a Bier block of up to 30 min after onset of ischemia. In contrast, Abeta-mediated touch sensation declined significantly. On the basis of these results, peripheral mechanisms of action could be verified for low-dose lidocaine and for morphine in the Bier block setting.
Conclusions:
The Bier-block setting can be successfully employed to differentiate peripheral and central modes of action of analgesics.
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