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GB virus type C/Hepatitis G virus

Jack T Stapleton1

  • 1Medical Service, Iowa City VA Hospital and Department of Internal Medicine, University of Iowa. Iowa City, Iowa 52242, USA. jack-stapleton@uiowa.edu

Seminars in Liver Disease
|June 12, 2003
PubMed

Insights

Hepatitis G virus (HGV), also known as GB virus type C (GBV-C), is a common human virus. GBV-C infection may prolong survival in HIV-positive individuals and inhibit HIV replication.

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Hepatitis G virus (HGV) and GB virus type C (GBV-C) are distinct isolates of the same virus, sharing genomic similarities with Hepatitis C virus.
  • HGV/GBV-C infection is prevalent in humans but not linked to liver disease, as it replicates in lymphocytes, not hepatocytes.

Purpose of the Study:

  • To investigate the potential impact of GBV-C infection on HIV-positive individuals.
  • To explore the interaction between GBV-C and HIV in human lymphocytes.

Main Methods:

  • Review of existing studies on HGV/GBV-C prevalence and disease association.
  • In vitro coinfection experiments using human lymphocytes with GBV-C and HIV.

Main Results:

  • GBV-C infection is not associated with hepatitis or other known diseases.
  • GBV-C infection in HIV-positive individuals correlates with prolonged survival.
  • In vitro studies show GBV-C coinfection decreases HIV replication in human lymphocytes.

Conclusions:

  • GBV-C's replication in lymphocytes, not hepatocytes, explains its lack of association with liver disease.
  • The interaction between GBV-C and HIV suggests potential therapeutic strategies for HIV/AIDS treatment.

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