[Neuromyalgic syndrome in children's infections]
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Published on: October 29, 2014
Insights
Neuromyalgic syndrome (NMS) is a newly described condition in children following viral infections, causing temporary nerve and muscle dysfunction. This research differentiates NMS from polyneuropathy, aiding in accurate diagnosis.
Area of Science:
- Neurology
- Pediatrics
- Infectious Diseases
Context:
- Neuromyalgic syndrome (NMS) is clinically and electroneuromyographically (ENMG) described for the first time in 50 children aged 2-13.
- NMS presents post-infection with acute respiratory viral infections (ARVI), intestinal, and parotitoviral infections.
- It involves transient peripheral nervous system and muscle dysfunction lasting 3-6 days.
Purpose:
- To clinically and electroneuromyographically (ENMG) describe Neuromyalgic Syndrome (NMS) in children.
- To differentiate NMS from other neurological conditions like polyneuropathy, viral meningitis, and ARVI.
- To explore potential mechanisms of NMS development, including inflammatory muscular reactions and nerve conductivity disorders.
Summary:
- NMS is characterized by muscle pain and peripheral nerve pain, predominantly affecting lower limb muscles, with rare generalized forms.
- Electroneuromyography (ENMG) reveals three types of nerve conductivity and excitability changes without conductive blocks, distinguishing it from polyneuropathy.
- Transient, non-specific inflammatory muscular reactions and functional nerve disorders are proposed mechanisms.
Impact:
- Establishes NMS as a distinct clinical entity in children following viral infections.
- Provides diagnostic criteria to differentiate NMS from polyneuropathy and other post-infectious neurological complications.
- Highlights the importance of ENMG in diagnosing pediatric neurological disorders.
Abstract:
Neuromyalgic syndrome (NMS) is clinically and electroneuromyographically (ENMG) first-ever described in 50 children aged 2-13. Muscular pains and pains along peripheral nerves occur in post-infection period of acute respiratory viral infections (ARVI), intestinal and parotitoviral infections with transient (in 3-6 days), dysfunction of peripheral nervous system and muscles. NMS is characterized by predominant involvement of lower limb muscles in pathologic process and by rarely developing generalized form. There are 3 types of changes of nerve conductivity and excitability with conductive blocks absence and disturbances regression that enable to distinguish these dysfunctions from ENMG changes in polyneuropathy. Provoked by infection, transitory non-specific inflammatory muscular reaction and functional disorders of nerve conductivity and excitability may be considered as one of the possible mechanisms of NMS development. More than 20 years of clinical and research experience of in neuroinfections clinic, supports the validity of NMS distinguishing among children acute infections for further diagnostic differentiation with polyneuropathy, viral meningitis and ARVI.
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