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Related Experiment Videos

Calprotectin levels in meconium.

N Laforgia1, M E Baldassarre, G Pontrelli

  • 1Dipartimento di Biomedicina dell'Età Evolutiva, Sez. Neonatologia e Terapia Intensiva Neonatale, Università di Bari, Italy. n.laforgia@neonatologia.uniba.it

Acta Paediatrica (Oslo, Norway : 1992)
|June 13, 2003
PubMed
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Calprotectin is present in meconium, with higher levels in preterm and low birthweight neonates. These levels correlate with lower 5-minute Apgar scores, suggesting potential intestinal issues.

Area of Science:

  • Neonatal physiology
  • Gastrointestinal biomarkers

Background:

  • Calprotectin is an inflammatory protein.
  • Meconium composition offers insights into fetal and neonatal health.

Purpose of the Study:

  • To investigate factors influencing calprotectin levels in neonatal meconium.
  • To explore correlations between meconium calprotectin and perinatal variables.

Main Methods:

  • Calprotectin concentration was measured in the meconium of 131 neonates.
  • Statistical analysis assessed correlations with gestational age, birthweight, Apgar score, delivery mode, gender, and maternal conditions.

Main Results:

  • Meconium calprotectin levels averaged 145.2 +/- 78.5 mg/kg.
  • Significant negative correlations were observed with birthweight (r = -0.333), gestational age (r = -0.206), and 5-minute Apgar score (r = -0.243).

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  • No significant differences were found based on gender, delivery mode, or maternal conditions.

    • Conclusions:

    • Calprotectin is present in meconium, with elevated levels in preterm, low birthweight, and potentially asphyxiated neonates.
    • Higher calprotectin may indicate intestinal mucosal immaturity and hypoxic-ischemic damage.
    • Meconium calprotectin serves as a potential biomarker for neonatal intestinal health.