Regulation of PPAR-gamma gene in human promyelocytic HL-60 cell line

The present study employed human promyelocytic cell line, HL-60, as an archetype model to understand the role of cholesterol receptors (Receptor-C(k) and oxysterol-specific receptor-transcription factor LxR-alpha) in the regulation of PPAR-gamma gene recognized to control cellular differentiation and apoptosis. Such a study revealed that Receptor "C(k)"-dependent signalling pathway not only regulates PPAR-gamma gene transcription but also provides ligands for the activation of this nuclear receptor superfamily of transcription factors that control hematopoiesis. Based upon these and our earlier results, we propose a molecular cross-talk pathway between cholesterol-specific cell surface Receptor-C(k) and nuclear receptors (LxR-alpha and PPAR-gamma), which may add a new dimension in the understanding and control of leukemogenesis.