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Updated: Aug 14, 2026
08:40
Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
Published on: August 23, 2022
[10 acute-phase reactive proteins and burn metabolism]
1Burn Research Institute, Southwestern Hospital, Third Military Medical College, PLA.
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi = Zhonghua Zheng Xing Shao Shang Waikf [I.E. Waike] Zazhi = Chinese Journal of Plastic Surgery and Burns
|June 1, 1992
Summary
Burn injury alters acute-phase proteins, impacting metabolism. Certain proteins like C-reactive protein (CRP) correlate with energy expenditure and nitrogen levels post-burn.
Area of Science:
- Biochemistry
- Physiology
- Trauma Medicine
Context:
- Burn injuries trigger a systemic inflammatory response known as the acute-phase reaction.
- Metabolic changes, including increased energy expenditure, are critical in burn patient recovery.
- Understanding the interplay between inflammation and metabolism is vital for effective burn management.
Purpose:
- To investigate the relationship between specific serum acute-phase proteins and metabolic parameters in adult burn patients.
- To identify potential biomarkers for predicting metabolic changes following severe burns.
Summary:
- Ten serum acute-phase proteins, resting energy expenditure (REE), hormones, and urine nitrogen were monitored in 23 adults with 40%-60% TBSA burns from injury to day 10 postburn.
- Levels of prealbumin (Palb), transferrin (TF), fibronectin (FN), and ceruloplasmin (CP) decreased post-burn.
- Alpha-1-antitrypsin (a-AT), C3c, and C4 initially decreased then increased, exceeding normal levels by day 10. C-reactive protein (CRP), haptoglobin (HP), and alpha-1-acid glycoprotein (a-AG) increased, correlating directly with REE and urine nitrogen.
Impact:
- Identifies CRP, a-AG, and HP as potential indicators for predicting energy expenditure changes in burn patients.
- Highlights the dynamic changes in acute-phase proteins following burn injury.
- Provides insights into the metabolic consequences of the acute-phase reaction in severe burns.
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