Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lung function in acute paraquat intoxication.

M Vízek, R Holusa, F Palecek

    Physiologia Bohemoslovaca
    |January 1, 1975
    PubMed
    Summary

    Paraquat herbicide causes lung injury in rats, leading to rapid breathing and altered lung capacity. Vagal nerve function significantly influences this paraquat-induced lung pathology.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Depletion of alveolar macrophages attenuates hypoxic pulmonary hypertension but not hypoxia-induced increase in serum concentration of MCP-1.

    Physiological research·2016
    Same author

    The contractile response of isolated small pulmonary arteries induced by activated macrophages.

    Physiological research·2014
    Same author

    Hypercapnia attenuates the hypoxia-induced blunting of the reactivity in chronically hypoxic rats.

    Physiological research·2013
    Same author

    Reactive oxygen species production in the early and later stage of chronic ventilatory hypoxia.

    Physiological research·2012
    Same author

    Lung mast cells and hypoxic pulmonary hypertension.

    Physiological research·2011
    Same author

    Disodium cromoglycate attenuates hypoxia induced enlargement of end-expiratory lung volume in rats.

    Physiological research·2011

    Area of Science:

    • Toxicology
    • Pulmonary Medicine
    • Physiology

    Background:

    • Paraquat is a widely used herbicide.
    • Paraquat exposure can cause severe lung damage.
    • The mechanisms underlying paraquat-induced lung injury require further investigation.

    Purpose of the Study:

    • To investigate the functional and morphological effects of paraquat on rat lungs.
    • To determine the role of vagal nerve function in paraquat-induced lung pathology.

    Main Methods:

    • Intratracheal injection of paraquat (0.5 mg/kg) in rats.
    • Measurement of breathing rate (tachypnoea) in conscious and anesthetized rats.
    • Assessment of functional residual lung capacity.
    • Histological examination of lung tissue.
    • Bilateral cervical vagotomy to assess vagal nerve influence.

    Main Results:

    • Paraquat induced pronounced tachypnoea (rapid breathing) in rats.
    • Functional residual lung capacity was significantly increased post-paraquat exposure.
    • Histology revealed hyaline membranes, oedema, haemorrhages, and inflammation.
    • Bilateral vagotomy normalized breathing rate and functional residual capacity in paraquat-exposed rats.

    Conclusions:

    • Paraquat herbicide causes significant acute lung injury in rats.
    • Vagal nerve function plays a critical role in the development of paraquat-induced lung pathology.
    • Targeting vagal pathways may offer therapeutic potential for paraquat poisoning.

    Related Experiment Videos