Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Food Intake

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

pH-Dependent Silica Nanoshell Degradation Influences SERRS Enhancement in Biological Environments.

bioRxiv : the preprint server for biology·2026

Same author

A double-blind randomized clinical trial of zonisamide and contingency management for alcohol use disorder treatment (ZARRA) protocol.

Contemporary clinical trials·2026

Same author

Prediction of acute kidney injury in patients with acute pesticide poisoning using the PKIP score.

Scientific reports·2026

Same author

Commentary on Getty et al.: Complementarity of harm reduction and contingency management.

Addiction (Abingdon, England)·2026

Same author

The Pharmaceutically Enhanced Reinforcement for Reduced Alcohol and Smoking (PERRAS) Study: Protocol for a randomized clinical trial.

Contemporary clinical trials·2025

Same author

Anti-obesity effect of unsaponifiable matter from hemp seed in 3T3-L1 adipocytes and high-fat diet-induced obese mice.

Food & function·2025

Same journal

Electroacupuncture alleviates neuroinflammation and promotes recovery of neurological functions after intracerebral hemorrhage by modulating α7nAChR/JAK2/STAT3 signaling pathway.

Neuroreport·2026

Same journal

Non-cell-autonomous regulation of Bhlhb5 expression in cortical projection neurons by GABAergic interneuron development and position.

Neuroreport·2026

Same journal

C-C motif chemokine ligand 3 mediates inflammatory response via NLRP3 inflammasome and neuron damage after traumatic brain injury.

Neuroreport·2026

Same journal

Methyltransferase-like 14 alleviates neuronal ferroptosis in Alzheimer's disease by regulating the peroxiredoxin 6/apoptosis signal-regulating kinase 1 signaling pathway.

Neuroreport·2026

Same journal

Hand mental rotation reaction time reflects motor imagery strategy and predicts changes in finger dexterity after motor imagery.

Neuroreport·2026

Same journal

Functional exploration of metabotropic glycine receptors in cultured rat hippocampal slices.

Neuroreport·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 5, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Published on: August 24, 2016

Extracellular glutamate decrease in accumbens following cued food delivery.

Mary Ann Chapman¹, John M Roll, Samuel Park

¹Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Cellular and Clinical Neurobiology and Substance Abuse Division, USA.

|June 13, 2003

Summary

This summary is machine-generated.

Predictive cues decrease glutamate release in the rat brain nucleus accumbens after food consumption. Dopamine release increased regardless of cue exposure, suggesting distinct neurochemical responses to food cues.

More Related Videos

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models

Published on: May 3, 2017

A High-content Assay for Monitoring AMPA Receptor Trafficking

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

Related Experiment Videos

Last Updated: May 5, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Published on: August 24, 2016

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models

Published on: May 3, 2017

A High-content Assay for Monitoring AMPA Receptor Trafficking

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

Area of Science:

Neuroscience
Behavioral Neuroscience
Neurochemistry

Background:

The brain's reward system, particularly the nucleus accumbens, plays a crucial role in motivated behaviors like food consumption.
Dopamine and glutamate are key neurotransmitters involved in reward processing and learning within the nucleus accumbens.

Purpose of the Study:

To investigate the impact of predictive auditory cues on extracellular glutamate and dopamine levels in the nucleus accumbens during food consumption in rats.
To differentiate the neurochemical responses associated with cued versus non-cued food delivery.

Main Methods:

Extracellular levels of glutamate and dopamine were measured in the nucleus accumbens of food-deprived rats using microdialysis.
Rats were divided into two groups: one exposed to auditory tones paired with food delivery (cued) and another without prior tone-food pairing (non-cued).
Neurotransmitter levels were monitored during and after food consumption.

Main Results:

Food consumption led to a significant decrease in extracellular glutamate in the nucleus accumbens of rats that received cued food delivery (p<0.05).
No significant decrease in extracellular glutamate was observed in rats without prior tone-food pairing.
Extracellular dopamine levels significantly increased in the nucleus accumbens post-consumption in both cued and non-cued groups (p<0.05).

Conclusions:

Food delivery paired with predictive environmental cues significantly modulates extracellular glutamate release in the nucleus accumbens.
The observed dopamine release appears to be a general response to food consumption, independent of cue-predictive learning.
These findings highlight the role of associative learning in shaping neurochemical responses within the brain's reward circuitry.