Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inductive activity of retinal peptides.

V Kh Khavinson1, V V Malinin, S V Trofimova

  • 1St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, Moscow.

Bulletin of Experimental Biology and Medicine
|June 13, 2003
PubMed
Summary

Retinalamin polypeptide influences early frog development. Its concentration controls the differentiation of ectodermal cells into neural tissues like the brain and retina.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.]

Advances in gerontology = Uspekhi gerontologii·2025
Same author

Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer's Disease.

Bulletin of experimental biology and medicine·2021
Same author

Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19.

Stem cell reviews and reports·2021
Same author

Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells.

Bulletin of experimental biology and medicine·2020
Same author

Comparison of the Effects of KE and AED Peptides on Functional Activity of Human Skin Fibroblasts during Their Replicative Aging.

Bulletin of experimental biology and medicine·2020
Same author

Peptide KE in Human Proteome.

Bulletin of experimental biology and medicine·2020

Area of Science:

  • Developmental biology
  • Cell differentiation
  • Neuroscience

Background:

  • Multipotent ectodermal cells in early Xenopus laevis gastrula are crucial for forming various cell types.
  • Understanding the molecular signals that guide neuronal differentiation is key to developmental studies.

Purpose of the Study:

  • To investigate the role of the retinal polypeptide Retinalamin in directing the differentiation of early ectodermal cells.
  • To determine the concentration-dependent effects of Retinalamin on neural tissue formation.

Main Methods:

  • Exposure of early Xenopus laevis gastrula ectoderm to varying concentrations of Retinalamin.
  • Analysis of cellular differentiation, focusing on neuronal lineages including brain, retina, and pigment epithelium.

Related Experiment Videos

Main Results:

  • Retinalamin significantly impacts the differentiation of multipotent ectodermal cells.
  • Neuronal differentiation, specifically for brain, retina, and pigment epithelium, was observed to be dependent on Retinalamin concentration.

Conclusions:

  • Retinalamin acts as a critical signaling molecule in early Xenopus development.
  • The concentration of Retinalamin directly influences the specification of neural cell fates from the ectoderm.