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ONO-1714 (Ono)

Brendan J R Whittle1

  • 1William Harvey Research Institute, St Bartholomew's & the Royal London, School of Medicine & Dentistry, Charterhouse Square, London, EC1M 6BQ, UK. b.j.whittle@mds.qmw.ac.uk

Idrugs : the Investigational Drugs Journal
|June 13, 2003
PubMed

Insights

Ono Pharmaceuticals is developing ONO-1714, a selective inducible nitric oxide synthase modulator, for sepsis and hypotension. Clinical trials were ongoing as of June 2002, with a projected market launch in 2004.

Area of Science:

  • Pharmacology
  • Clinical Trials
  • Drug Development

Background:

  • Ono Pharmaceuticals is developing ONO-1714.
  • ONO-1714 is a selective inducible nitric oxide synthase (iNOS) modulator.
  • The drug is intended for the potential treatment of sepsis and hypotension.

Purpose of the Study:

  • To assess the safety and efficacy of ONO-1714 in clinical trials.
  • To evaluate ONO-1714 for the treatment of hypotension during dialysis.
  • To conduct clinical pharmacology trials for ONO-1714.

Main Methods:

  • Phase I trials initiated by March 1999.
  • Phase II trial for hypotension during dialysis ongoing in Japan by June 2002.
  • Clinical pharmacology trials conducted in the UK.

Main Results:

  • ONO-1714 entered Phase I trials in March 1999.
  • A Phase II trial for hypotension during dialysis was in progress by June 2002.
  • Clinical pharmacology trials were underway in the UK.

Conclusions:

  • ONO-1714 is under investigation for sepsis and hypotension.
  • Clinical development progressed through Phase II trials.
  • Market launch was projected for 2004 with significant sales expectations.

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