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Gender differences in left ventricular function in patients with isolated aortic stenosis.

Luca Favero¹, Massimo Giordan, Giuseppe Tarantini

¹Department of Interventional Cardiology, University of Padova Medical School, Padova, Italy.

The Journal of Heart Valve Disease

|June 14, 2003

Summary

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In aortic stenosis, women showed higher pressures and stress but a trend towards less left ventricular (LV) mass increase compared to men. LV pump function remained normal in both genders.

Area of Science:

Cardiology
Cardiovascular Physiology
Clinical Medicine

Background:

Aortic stenosis (AS) causes left ventricular (LV) systolic overload.
The hypertrophic response to AS may differ between genders.

Purpose of the Study:

To investigate gender-specific differences in LV function in patients with isolated severe AS.

Main Methods:

145 patients (65 women, 80 men) with severe AS (aortic valve area <0.8 cm2) underwent cardiac catheterization.
Exclusion criteria included diabetes, hypertension, and other cardiac/valve diseases.

Main Results:

No significant differences in aortic valve area or LV volumes/mass between genders.
Women exhibited higher transaortic gradient, LV peak systolic pressure, and cardiac index.

Related Experiment Videos

Men showed increased LV mass:volume ratio in severe LV pressure subgroup (>199 mmHg).

Conclusions:

Despite similar hemodynamics, women trended towards a less compensatory increase in LV mass.
LV pump function was comparable between genders, even in severe pressure overload.