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Lipid profile before and after renal transplantation--a longitudinal study
H S Pannu1, D Singh, J S Sandhu
1Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Renal Failure
|June 14, 2003
Summary
Renal transplantation significantly elevates lipid and lipoprotein levels in patients, with immunosuppressive drugs suspected as the cause. This study provides crucial data on lipid profiles in Indian renal transplant recipients.
Area of Science:
- Nephrology
- Clinical Biochemistry
- Immunology
Background:
- Limited data exists on lipid profiles in renal transplant recipients from the Indian subcontinent.
- Understanding post-transplant lipid changes is crucial for patient management.
Purpose of the Study:
- To investigate changes in lipid profiles before and after renal transplantation.
- To assess the impact of immunosuppressive therapy on lipid metabolism in renal allograft recipients.
Main Methods:
- Lipid profiles were analyzed in 30 end-stage renal disease patients pre-transplant and at 1, 3, and 6 months post-transplant.
- Results were compared with 30 healthy controls.
- Patients received triple immunosuppression: prednisolone, azathioprine, and cyclosporine.
Main Results:
- Pre-transplant, only HDL cholesterol was significantly lower than controls.
- Post-transplant, significant elevations in total cholesterol, triglycerides, VLDL, and LDL were observed.
- HDL cholesterol remained significantly lower post-transplant; diabetic status did not significantly alter lipid profiles in recipients.
Conclusions:
- Renal transplantation leads to distinct elevations in lipids and lipoproteins.
- Immunosuppressive drugs are implicated as the primary cause of these dyslipidemias.