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Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
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Increased urinary excretion of monocyte chemoattractant protein-1 in proteinuric renal diseases

Tsukasa Morii1, Hiroki Fujita, Takuma Narita

  • 1Department of Geriatric Medicine, Akita University School of Medicine, Hondo, Akita, Japan. morii@med.akita-u.ac.jp

Renal Failure
|June 14, 2003
PubMed

Insights

Monocyte chemoattractant protein-1 (MCP-1) is elevated in proteinuric kidney diseases, including diabetic nephropathy and IgA nephropathy. This suggests MCP-1 contributes to kidney tubule damage in these conditions.

Area of Science:

  • Nephrology
  • Immunology
  • Molecular Biology

Background:

  • Monocyte chemoattractant protein-1 (MCP-1) is a key chemokine implicated in renal interstitial inflammation and fibrosis.
  • Elevated urinary MCP-1 correlates with albuminuria and N-acetylglucosaminidase (NAG) in type 2 diabetic patients, suggesting it exacerbates tubular damage in diabetic nephropathy.
  • The role of MCP-1 in other proteinuric kidney diseases remains less understood.

Purpose of the Study:

  • To investigate whether urinary MCP-1 excretion is increased in proteinuric states beyond diabetic nephropathy.
  • To compare MCP-1 levels in IgA nephropathy patients with macroalbuminuria to those with and without diabetic nephropathy.

Main Methods:

  • Urinary MCP-1 levels were measured in three groups: non-diabetic nephropathy (non-DN, n=27), diabetic nephropathy (DN, n=23), and IgA nephropathy with macroalbuminuria (IgAN, n=6).
  • Urinary NAG levels were also assessed.
  • Statistical comparison of MCP-1 and NAG excretion between groups was performed.

Main Results:

  • Urinary MCP-1 excretion levels were significantly higher in both the DN group (346.1 ng/g creatinine) and the IgAN group (274.4 ng/g creatinine) compared to the non-DN group (157.2 ng/g creatinine).
  • Urinary NAG levels were also significantly elevated in DN and IgAN groups compared to the non-DN group.
  • MCP-1 levels showed a median range of 147.0-1276.7 in DN and 162.2-994.5 in IgAN.

Conclusions:

  • Urinary MCP-1 expression is enhanced in proteinuric states, irrespective of the underlying renal disease type.
  • Increased MCP-1 likely contributes to renal tubular damage in various proteinuric kidney conditions.
  • MCP-1 serves as a potential biomarker for tubular damage in proteinuric kidney diseases.

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