Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HTLV-1 and its neurological complications.

R B Khan1, T E Bertorini, M C Levin

  • 1Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

The Neurologist
|June 14, 2003
PubMed
Summary

Human T-cell lymphotropic virus type-1 (HTLV-1) is linked to neurological conditions like HTLV-1-associated myelopathy. While HTLV-1 infection is widespread, only a small fraction of infected individuals develop these serious neurological diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An association of VDR gene polymorphism in hypovitaminosis D mediated secondary hyperparathyroidism in adolescent girls; a tertiary hospital study in central India.

Steroids·2022
Same author

Pretreatment Normal WM Magnetization Transfer Ratio Predicts Risk of Radiation Necrosis in Patients with Medulloblastoma.

AJNR. American journal of neuroradiology·2022
Same author

Concentration-dependent effect of fumonisin B<sub>1</sub> on apoptosis in oesophageal cancer cells.

Human & experimental toxicology·2017
Same author

Evaluation of macrophage-specific promoters using lentiviral delivery in mice.

Gene therapy·2011
Same author

Randomized, blinded trial of weekend vs daily prednisone in Duchenne muscular dystrophy.

Neurology·2011
Same author

"Not multiple sclerosis" and the changing face of HTLV-1: a case report of downbeat nystagmus.

Neurology·2009

Area of Science:

  • Neurology
  • Virology
  • Infectious Diseases

Background:

  • Human T-cell lymphotropic virus type-1 (HTLV-1), discovered in 1980, is globally distributed.
  • HTLV-1 infection affects up to 30% of populations in endemic areas.
  • Only a small percentage of HTLV-1 infected individuals develop associated neurological diseases.

Purpose of the Study:

  • To review the association between HTLV-1 infection and neurological diseases.
  • To highlight the challenges in treating HTLV-1-associated neurological conditions.
  • To emphasize the need for further research and clinical trials.

Main Methods:

  • Review of existing literature on HTLV-1 and neurological manifestations.
  • Analysis of reported cases and epidemiological data.

Related Experiment Videos

  • Identification of knowledge gaps in treatment and understanding of pathophysiology.

    • Main Results:

    • HTLV-1 infection is associated with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), polymyositis, and uveitis.
    • Some patients present with multiple HTLV-1-associated syndromes.
    • Limited epidemiological data exists for other neurological syndromes in HTLV-1 infected individuals.
    • Treatment for HTLV-1-associated neurological disease is challenging, with a lack of well-controlled studies.

    Conclusions:

    • Understanding HTLV-1 pathophysiology is crucial for developing improved therapies.
    • Randomized clinical trials with extended follow-up are necessary.
    • Further research is required to assess treatment effects on patient disability and quality of life.