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Capillary electrophoretic behaviors of pharmacologically active xanthones from Securidaca inappendiculata with
Tao Bo1, Yongfa Huang, Xuedong Yang
1Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, P.R. China.
Abstract:
The capillary electrophoretic (CE) behaviors of ten xanthones in the presence of beta-cyclodextrin (CD) are investigated, and apparent analyte-selector binding constants between beta-CD and the xanthones in the CE running buffer are calculated to elucidate the migration order. Also, the separation selectivity with beta-CD additive is compared with that of sulfated beta-CD additive. It is indicated that beta-CD can greatly change the separation selectivity of xanthones, and the electrophoretic behaviors of xanthones are rather different when using beta-CD from that when using sulfated beta-CD as an additive.