Related Experiment Video
Updated: Aug 11, 2026

Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer
Published on: January 29, 2020
Hypercarotenaemia or hypercarotenoidaemia
R Saldana Chaparro1, E Carr, J L Barron
1Department of Chemical Pathology and Metabolism, St Helier Hospital, Carshalton SM5 1AA, UK.
Background:
Serum carotenoids consist of a variety of different compounds. Xanthoderma may result from an increased concentration of any of the carotenoids.
Methods And Results:
High-performance liquid chromatography of serum carotenoids shows that a normal chromatogram contains mainly beta-carotene, lutein and lycopene. Serum alpha- and beta-carotene, beta-cryptoxanthin, lycopene, lutein and zeaxanthin were found to be increased in the investigation of hypercarotenaemia.
Conclusion:
Patients presenting with possible xanthoderma should have a dietary history taken and serum sent for carotenoid analysis.
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