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Related Experiment Videos

Glycosphingolipid functions: insights from engineered mouse models.

Richard L Proia1

  • 1Genetics of Development and Disease Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1821, USA. proia@nih.gov

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|June 14, 2003
PubMed
Summary

Mutant mice lacking specific glycosphingolipids reveal their profound physiological functions. This review highlights new insights into these complex molecules and their roles in development and tissues.

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Area of Science:

  • Biochemistry
  • Glycobiology
  • Developmental Biology

Background:

  • Glycosphingolipids are complex structural molecules with diverse tissue-specific and developmental patterns.
  • Their physiological roles are significant but not fully understood.

Purpose of the Study:

  • To review the emerging understanding of glycosphingolipid physiological functions.
  • To highlight the contribution of studies involving mutant mice lacking specific glycosphingolipids.

Main Methods:

  • Analysis of glycosphingolipid-deficient mutant mouse models.
  • Characterization of structural complexity and expression patterns.

Main Results:

  • Mutant mouse studies provide critical new information on glycosphingolipid functions.

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  • Distinct patterns of glycosphingolipids are linked to specific tissues and developmental stages.

    • Conclusions:

    • Glycosphingolipids play profound physiological roles.
    • Studies using genetic models are key to deciphering their functions in health and disease.