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Updated: Jul 15, 2026

DiI-Labeling of DRG Neurons to Study Axonal Branching in a Whole Mount Preparation of Mouse Embryonic Spinal Cord
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Expression of DRG during murine embryonic development.

T Sazuka1, M Kinoshita, Y Tomooka

  • 1Laboratory of Molecular Oncology, RIKEN, Tsukuba Life Science Center, Ibaraki, Japan.

Biochemical and Biophysical Research Communications
|November 30, 1992
PubMed
Summary

The novel GTP-binding protein DRG (down-regulated gene) is expressed in embryonic tissues and adult cells, suggesting roles in development and cell metabolism.

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • A novel GTP-binding protein, DRG (down-regulated gene), was previously characterized.
  • The drg gene's expression is reduced during murine central nervous system embryonic development.

Purpose of the Study:

  • To investigate the expression pattern of drg mRNA and DRG protein in adult mouse tissues and cell lines.
  • To elucidate the potential roles of DRG in development and cellular metabolism.

Main Methods:

  • Analysis of drg mRNA and protein levels in various adult mouse tissues and cell lines.
  • In situ hybridization to examine drg mRNA expression in embryonic tissues.
  • Cellular localization studies of DRG protein.

Main Results:

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Last Updated: Jul 15, 2026

DiI-Labeling of DRG Neurons to Study Axonal Branching in a Whole Mount Preparation of Mouse Embryonic Spinal Cord
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  • DRG is expressed widely but at low and variable levels in adult tissues and cell lines.
  • drg mRNA is strongly expressed in various embryonic tissues, significantly reduced in newborn animals.
  • DRG protein is localized to the cytoplasm.

Conclusions:

  • DRG exhibits dynamic expression patterns during embryonic development.
  • The widespread expression in adult tissues suggests involvement in normal cell metabolism.
  • DRG likely plays multifaceted roles in both development and cellular functions.