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Dopamine agonists for cocaine dependence.

B G O Soares1, M S Lima, A A P Reisser

  • 1Psychiatry, São Paulo Federal University, Av Dr Altino Arantes 1132 apto 113, São Paulo, São Paulo, Brazil. bgos@terra.com.br

The Cochrane Database of Systematic Reviews
|June 14, 2003
PubMed
Summary
This summary is machine-generated.

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Dopamine agonists like amantadine, bromocriptine, and pergolide are not effective for treating cocaine dependence. Further research is needed to find treatments that improve patient retention in therapy.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Public Health

Background:

  • Cocaine dependence is a significant public health issue with severe medical, psychological, and social consequences.
  • Chronic cocaine use alters brain dopamine concentrations, suggesting dopamine-modulating drugs might aid treatment.
  • Withdrawal symptoms include craving, depression, fatigue, and sleep disturbances, complicating abstinence.

Purpose of the Study:

  • To assess the efficacy and acceptability of dopamine agonists in treating cocaine dependence.
  • To review randomized controlled trials investigating dopamine agonist therapies for cocaine addiction.

Main Methods:

  • Conducted comprehensive electronic database searches (Cochrane Library, EMBASE, MEDLINE, etc.) up to February 2003.
  • Included 17 randomized controlled trials with 1224 participants evaluating amantadine, bromocriptine, and pergolide.

Related Experiment Videos

  • Extracted data independently, estimating relative risks and weighted mean differences for efficacy and treatment retention.

    • Main Results:

    • No significant differences were found between dopamine agonist interventions and control groups.
    • Efficacy was measured by urine tests for cocaine metabolites; acceptability by treatment retention rates.
    • Results were consistent regardless of primary cocaine dependence or co-occurring opioid dependence.

    Conclusions:

    • Current evidence does not support the use of dopamine agonists for treating cocaine dependence.
    • High dropout rates in this population necessitate exploring additional supportive measures to enhance treatment adherence.