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Related Experiment Videos

Folate for depressive disorders.

M J Taylor1, S Carney, J Geddes

  • 1Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK, OX3 7JK. john.geddes@psych.ox.ac.uk

The Cochrane Database of Systematic Reviews
|June 14, 2003
PubMed
Summary

Folate supplementation may improve depression treatment outcomes when used alongside other therapies. This meta-analysis found folate reduced depression scores and increased remission rates, with no reported adverse effects.

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Area of Science:

  • Nutritional Psychiatry
  • Pharmacological Interventions for Mood Disorders

Background:

  • Standard depression treatments can be augmented with adjunctive therapies like folate.
  • Folate's potential role in enhancing antidepressant efficacy warrants investigation.

Purpose of the Study:

  • To evaluate the effectiveness of folate in treating depression.
  • To assess the safety and acceptability of folate as a treatment for depression.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) comparing folate with placebo or other antidepressants.
  • Searched multiple databases including EMBASE, MEDLINE, LILACS, CINAHL, PSYNDEX, and PsycLIT.
  • Independent data extraction and analysis using Review Manager software.

Main Results:

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  • Three RCTs with 247 participants were included.
  • Adjunctive folate therapy significantly reduced Hamilton Depression Rating Scale (HDRS) scores (mean difference 2.65 points).
  • Folate increased the likelihood of achieving a 50% HDRS score reduction (RR 0.47), with an NNT of 5.

Conclusions:

  • Limited evidence suggests folate may be a beneficial adjunct therapy for depression.
  • Further research is needed to clarify folate's efficacy in individuals with normal versus deficient folate levels.