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Heparin for pregnant women with acquired or inherited thrombophilias
M C Walker1, S E Ferguson, V M Allen
1Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada, K1H 8L6. mwalker99@hotmail.com
Background:
Thrombophilias, which are associated with a predisposition to thrombotic events, have been implicated in adverse obstetrical outcomes such as intrauterine growth restriction, stillbirth, severe early onset pre-eclampsia, and placental abruption. Heparin administration in pregnancy may reduce the risk of these events.
Objectives:
The objective of this review was to assess the effects of heparin on pregnancy outcomes for women with a thrombophilia.
Search Strategy:
We searched the Cochrane Pregnancy and Childbirth Group trials register (July 2002), MEDLINE, EMBASE, CINAHL, Scidex (via OVID Technologies - July 2002) and reference lists and personal files.
Selection Criteria:
Randomized controlled trials comparing heparin with placebo or no treatment, or randomized controlled trials comparing any two treatments. Quasi randomized studies would be included.
Data Collection And Analysis:
Data would be abstracted from identified studies and recorded on a paper form by two reviewers.
Main Results:
No studies were included.
Reviewer'S Conclusions:
There are no completed trials to determine the effects of heparin on pregnancy outcomes for women with a thrombophilia.
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